Keywords
Pospartum Haemorrhage
Oxytocin Intramuscular
Oxytocin Intravena
Vaginal Delivery
Oxytocin Intramuscular
Oxytocin Intravena
Vaginal Delivery
How to Cite
Cahyaningtyas, D. K., Rospia, E. D., & Agustina, R. (2023). Literature Review: Perbedaan Pemberian Oksitosin Profilaksis Secara Intravena dan Intramuskular Terhadap Kejadian Perdarahan Postpartum. Jurnal Kebidanan Malakbi, 4(1), 23–31. https://doi.org/10.33490/b.v4i1.689
Abstract
Postpartum Haemorrhage is a condition of blood loss of more than 500 cc that occurs within 24 hours after delivery. Postpartum hemorrhage is a significant cause of morbidity and mortality in childbirth. Postpartum Haemorrhage occurs in about 1% to 6% of all deliveries. Uterine atony, the leading cause of primary postpartum hemorrhage, accounts for 70% to 80% of all bleeding. Early prevention in postpartum hemorrhage cases is the usage of uterotonics in the third stage of labor which has become the standard of intervention worldwide. The choice of uterotonic in managing postpartum hemorrhage should be adjusted to the administration and dosage. This Study aims to analyze the difference in prophylactic administration of oxytocin injected in intramuscular and intravenous during postpartum hemorrhage. Data were searched using PICO, articles were selected using PRISMA, and critical appraisal. There is decreased postpartum hemorrhage compared to IM oxytocin administration. Intra Vena oxytocin administration could reduce the incidence of severe postpartum hemorrhage and prevent blood transfusions compared to IM oxytocin administration in the third stage of labor in postpartum hemorrhage. However, there was no significant difference in hemoglobin changes. The side effects caused by intravenous administration are still manageable compared to intramuscular administration. Intravenous oxytocin prevented postpartum hemorrhage in stage III more effectively than intramuscular administration. The side effects that emerged in the two groups of intravenous and intramuscular administration were not significantly different and were still within mild limits. The administration of oxytocin in preventing postpartum hemorrhage in the third stage of labor has become a procedure and recommendation of health organizations.
References
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Biradar, A. M., Yaliwal, R. G., Kori, S. S., Mathapati, S. S., Shiragur, S. S., & Mudanur, S. R. (2020). Randomised Control Trial of 3 IU Intravenous Oxytocin Bolus With 7 IU Oxytocin Infusion Versus 10 IU Intramuscular Oxytocin in the Third Stage of Labour in the Prevention of Postpartum Hemorrhage. International Journal of Women’s Health and Reproduction Sciences, 9(3), 171–175. https://doi.org/10.15296/ijwhr.2021.32
Charles, D., Anger, H., Dabash, R., Darwish, E., Ramadan, M. C., Mansy, A., Salem, Y., Dzuba, I. G., Byrne, M. E., Breebaart, M., & Winikoff, B. (2019). Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial. BMC Pregnancy and Childbirth, 19(1), 38. https://doi.org/10.1186/s12884-019-2181-2
Dagdeviren, H., Cengiz, H., Heydarova, U., Caypinar, S. S., Kanawati, A., Guven, E., & Ekin, M. (2016). Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study. Archives of Gynecology and Obstetrics, 294(5), 911–916. https://doi.org/10.1007/s00404-016-4060-7
Durocher, J., Dzuba, I. G., Carroli, G., Morales, E. M., Aguirre, J. D., Martin, R., Esquivel, J., Carroli, B., & Winikoff, B. (2019). Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial. PLOS ONE, 14(10), e0222981. https://doi.org/10.1371/journal.pone.0222981
Ebada, M. A., Elmatboly, A. M., & Baligh, G. (2021). Intravenous Oxytocin versus Intramuscular Oxytocin for the Management of Postpartum Hemorrhage: A Systematic Review and Meta-Analysis. Current Drug Research Reviews, 12(2), 150–157. https://doi.org/10.2174/2589977512666200628013647
Escobar, M. F., Füchtner, C. E., Carvajal, J. A., Nieto, A. J., Messa, A., Escobar, S. S., Monroy, A. M., Forero, A. M., Casallas, J. D., Granados, M., & Miller, S. (2017). Experience in the use of non-pneumatic anti-shock garment (NASG) in the management of postpartum haemorrhage with hypovolemic shock in the Fundación Valle Del Lili, Cali, Colombia. Reproductive Health, 14(1), 58. https://doi.org/10.1186/s12978-017-0325-2
Gülmezoglu, A. M., Crowther, C. A., Middleton, P., & Heatley, E. (2012). Induction of labour for improving birth outcomes for women at or beyond term. The Cochrane database of systematic reviews, 6(6). https://doi.org/10.1002/14651858.CD004945.PUB3
Halas, G., Schultz, A. S. H., Rothney, J., Goertzen, L., Wener, P., & Katz, A. (2015). A scoping review protocol to map the research foci trends in tobacco control over the last decade. BMJ Open, 5(1). https://doi.org/10.1136/bmjopen-2014-006643
Halder, A., Jose, R., & Vijayselvi, R. (2014). Maternal mortality and derivations from the WHO near-miss tool: An institutional experience over a decade in Southern India. Journal of the Turkish German Gynecological Association, 15(4), 222–227. https://doi.org/10.5152/jtgga.2014.14076
Jekti, R. P., & Mutiatikum, D. (2011). Hubungan Antara Kepatuhan Ante Natal Care Dengan Pemilihan Penolong Persalinan. Indonesian Journal of Reproductive Health, 1(2), 84–91. https://www.neliti.com/publications/105415/hubungan-antara-kepatuhan-ante-natal-care-dengan-pemilihan-penolong-persalinan#cite
KemenKes. (2020). Profil Kesehatan Indonesia 2020. https://doi.org/10.1524/itit.2006.48.1.6
Koh, P. R., Di Filippo, D., Bisits, A., & Welsh, A. W. (2020). Bimanual examination for clot evacuation: a retrospective cohort study of women with postpartum haemorrhage after vaginal delivery. BMC Pregnancy and Childbirth, 20(1), 245. https://doi.org/10.1186/s12884-020-02916-w
Kristianingsih, A., Mukhlis, H., & Ermawati, E. (2020). Faktor-faktor yang berhubungan dengan kejadian perdarahan postpartum di RSUD Pringsewu. Journal Wellnes, 2(February), 309–313. https://wellness.journalpress.id/wellness/article/download/v1i218wh/21
Oguz Orhan, E., Dilbaz, B., Aksakal, S. E., Altınbas, S., & Erkaya, S. (2014). Prospective randomized trial of oxytocin administration for active management of the third stage of labor. International Journal of Gynecology & Obstetrics, 127(2), 175–179. https://doi.org/10.1016/j.ijgo.2014.05.022
Oladapo, O. T., Okusanya, B. O., Abalos, E., Gallos, I. D., & Papadopoulou, A. (2020a). Intravenous versus intramuscular prophylactic oxytocin for the third stage of labour. The Cochrane database of systematic reviews, 11(11). https://doi.org/10.1002/14651858.CD009332.PUB4
Oladapo, O. T., Okusanya, B. O., Abalos, E., Gallos, I. D., & Papadopoulou, A. (2020b). Intravenous versus intramuscular prophylactic oxytocin for reducing blood loss in the third stage of labour. Cochrane Database of Systematic Reviews, 2020(12). https://doi.org/10.1002/14651858.CD009332.pub4
Peters, M. D. J., Godfrey, C. M., Khalil, H., McInerney, P., Parker, D., & Soares, C. B. (2015). Guidance for conducting systematic scoping reviews. International Journal of Evidence-Based Healthcare, 13(3), 141–146. https://doi.org/10.1097/XEB.0000000000000050
Sangkomkamhang, U., & Kruangpatee, A. (2015). A Randomised Controlled Trial of Intravenous versus Intramuscular Oxytocin in the Prevention of Postpartum Hemorrhage during the Third Stage of Labor. Journal of Health Science-วารสาร วิชาà¸à¸²à¸£ สาธารณสุข, 24(2), 354–359. https://thaidj.org/index.php/JHS/article/view/451/401
Say, L., Chou, D., Gemmill, A., Tunçalp, Ö., Moller, A.-B., Daniels, J., Gülmezoglu, A. M., Temmerman, M., & Alkema, L. (2014). Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health, 2(6), e323–e333. https://doi.org/10.1016/S2214-109X(14)70227-X
Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., … Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
Tunçalp, Ö., Souza, J. P., & Gülmezoglu, M. (2013). New WHO recommendations on prevention and treatment of postpartum hemorrhage. International Journal of Gynecology & Obstetrics, 123(3), 254–256. https://doi.org/10.1016/j.ijgo.2013.06.024
Wormer, K. C., Jamil, R. T., & Bryant, S. B. (2022). Acute Postpartum Hemorrhage. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK499988/
Yulianto Sarim, B. (2020). Manajemen Perioperatif pada Perdarahan akibat Atonia Uteri. Jurnal Anestesi Obstetri Indonesia, 3(1), 47–58. https://doi.org/10.47507/obstetri.v3i1.42
Zhou, Y., Xie, Y., Luo, Y.-Z., Liu, X.-W., Zhou, J., & Liu, Q. (2020). Intramuscular versus intravenous oxytocin for the third stage of labor after vaginal delivery to prevent postpartum hemorrhage: a meta-analysis of randomized controlled trials. European Journal of Obstetrics & Gynecology and Reproductive Biology, 250(2019), 265–271. https://doi.org/10.1016/j.ejogrb.2020.04.007
Arnov, J., Bisri, Y., & Suwarman. (2017). Perbandingan Efek Metilergometrin Maleat antara Pemberian Intravena dan Intramuskular yang Dikombinasikan dengan Drip Oksitosin terhadap Kontraksi Uterus dan Tekanan Darah pada Seksio Sesarea Elektif dengan Anestesi Umum Comparison Between Methylergometri. 4, 78–85. https://macc.perdatin.org/index.php/my-journal/article/view/152
Baron, R. M., & Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51(6), 1173–1182. https://doi.org/10.1037/0022-3514.51.6.1173
Biradar, A. M., Yaliwal, R. G., Kori, S. S., Mathapati, S. S., Shiragur, S. S., & Mudanur, S. R. (2020). Randomised Control Trial of 3 IU Intravenous Oxytocin Bolus With 7 IU Oxytocin Infusion Versus 10 IU Intramuscular Oxytocin in the Third Stage of Labour in the Prevention of Postpartum Hemorrhage. International Journal of Women’s Health and Reproduction Sciences, 9(3), 171–175. https://doi.org/10.15296/ijwhr.2021.32
Charles, D., Anger, H., Dabash, R., Darwish, E., Ramadan, M. C., Mansy, A., Salem, Y., Dzuba, I. G., Byrne, M. E., Breebaart, M., & Winikoff, B. (2019). Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial. BMC Pregnancy and Childbirth, 19(1), 38. https://doi.org/10.1186/s12884-019-2181-2
Dagdeviren, H., Cengiz, H., Heydarova, U., Caypinar, S. S., Kanawati, A., Guven, E., & Ekin, M. (2016). Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study. Archives of Gynecology and Obstetrics, 294(5), 911–916. https://doi.org/10.1007/s00404-016-4060-7
Durocher, J., Dzuba, I. G., Carroli, G., Morales, E. M., Aguirre, J. D., Martin, R., Esquivel, J., Carroli, B., & Winikoff, B. (2019). Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial. PLOS ONE, 14(10), e0222981. https://doi.org/10.1371/journal.pone.0222981
Ebada, M. A., Elmatboly, A. M., & Baligh, G. (2021). Intravenous Oxytocin versus Intramuscular Oxytocin for the Management of Postpartum Hemorrhage: A Systematic Review and Meta-Analysis. Current Drug Research Reviews, 12(2), 150–157. https://doi.org/10.2174/2589977512666200628013647
Escobar, M. F., Füchtner, C. E., Carvajal, J. A., Nieto, A. J., Messa, A., Escobar, S. S., Monroy, A. M., Forero, A. M., Casallas, J. D., Granados, M., & Miller, S. (2017). Experience in the use of non-pneumatic anti-shock garment (NASG) in the management of postpartum haemorrhage with hypovolemic shock in the Fundación Valle Del Lili, Cali, Colombia. Reproductive Health, 14(1), 58. https://doi.org/10.1186/s12978-017-0325-2
Gülmezoglu, A. M., Crowther, C. A., Middleton, P., & Heatley, E. (2012). Induction of labour for improving birth outcomes for women at or beyond term. The Cochrane database of systematic reviews, 6(6). https://doi.org/10.1002/14651858.CD004945.PUB3
Halas, G., Schultz, A. S. H., Rothney, J., Goertzen, L., Wener, P., & Katz, A. (2015). A scoping review protocol to map the research foci trends in tobacco control over the last decade. BMJ Open, 5(1). https://doi.org/10.1136/bmjopen-2014-006643
Halder, A., Jose, R., & Vijayselvi, R. (2014). Maternal mortality and derivations from the WHO near-miss tool: An institutional experience over a decade in Southern India. Journal of the Turkish German Gynecological Association, 15(4), 222–227. https://doi.org/10.5152/jtgga.2014.14076
Jekti, R. P., & Mutiatikum, D. (2011). Hubungan Antara Kepatuhan Ante Natal Care Dengan Pemilihan Penolong Persalinan. Indonesian Journal of Reproductive Health, 1(2), 84–91. https://www.neliti.com/publications/105415/hubungan-antara-kepatuhan-ante-natal-care-dengan-pemilihan-penolong-persalinan#cite
KemenKes. (2020). Profil Kesehatan Indonesia 2020. https://doi.org/10.1524/itit.2006.48.1.6
Koh, P. R., Di Filippo, D., Bisits, A., & Welsh, A. W. (2020). Bimanual examination for clot evacuation: a retrospective cohort study of women with postpartum haemorrhage after vaginal delivery. BMC Pregnancy and Childbirth, 20(1), 245. https://doi.org/10.1186/s12884-020-02916-w
Kristianingsih, A., Mukhlis, H., & Ermawati, E. (2020). Faktor-faktor yang berhubungan dengan kejadian perdarahan postpartum di RSUD Pringsewu. Journal Wellnes, 2(February), 309–313. https://wellness.journalpress.id/wellness/article/download/v1i218wh/21
Oguz Orhan, E., Dilbaz, B., Aksakal, S. E., Altınbas, S., & Erkaya, S. (2014). Prospective randomized trial of oxytocin administration for active management of the third stage of labor. International Journal of Gynecology & Obstetrics, 127(2), 175–179. https://doi.org/10.1016/j.ijgo.2014.05.022
Oladapo, O. T., Okusanya, B. O., Abalos, E., Gallos, I. D., & Papadopoulou, A. (2020a). Intravenous versus intramuscular prophylactic oxytocin for the third stage of labour. The Cochrane database of systematic reviews, 11(11). https://doi.org/10.1002/14651858.CD009332.PUB4
Oladapo, O. T., Okusanya, B. O., Abalos, E., Gallos, I. D., & Papadopoulou, A. (2020b). Intravenous versus intramuscular prophylactic oxytocin for reducing blood loss in the third stage of labour. Cochrane Database of Systematic Reviews, 2020(12). https://doi.org/10.1002/14651858.CD009332.pub4
Peters, M. D. J., Godfrey, C. M., Khalil, H., McInerney, P., Parker, D., & Soares, C. B. (2015). Guidance for conducting systematic scoping reviews. International Journal of Evidence-Based Healthcare, 13(3), 141–146. https://doi.org/10.1097/XEB.0000000000000050
Sangkomkamhang, U., & Kruangpatee, A. (2015). A Randomised Controlled Trial of Intravenous versus Intramuscular Oxytocin in the Prevention of Postpartum Hemorrhage during the Third Stage of Labor. Journal of Health Science-วารสาร วิชาà¸à¸²à¸£ สาธารณสุข, 24(2), 354–359. https://thaidj.org/index.php/JHS/article/view/451/401
Say, L., Chou, D., Gemmill, A., Tunçalp, Ö., Moller, A.-B., Daniels, J., Gülmezoglu, A. M., Temmerman, M., & Alkema, L. (2014). Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health, 2(6), e323–e333. https://doi.org/10.1016/S2214-109X(14)70227-X
Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., … Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
Tunçalp, Ö., Souza, J. P., & Gülmezoglu, M. (2013). New WHO recommendations on prevention and treatment of postpartum hemorrhage. International Journal of Gynecology & Obstetrics, 123(3), 254–256. https://doi.org/10.1016/j.ijgo.2013.06.024
Wormer, K. C., Jamil, R. T., & Bryant, S. B. (2022). Acute Postpartum Hemorrhage. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK499988/
Yulianto Sarim, B. (2020). Manajemen Perioperatif pada Perdarahan akibat Atonia Uteri. Jurnal Anestesi Obstetri Indonesia, 3(1), 47–58. https://doi.org/10.47507/obstetri.v3i1.42
Zhou, Y., Xie, Y., Luo, Y.-Z., Liu, X.-W., Zhou, J., & Liu, Q. (2020). Intramuscular versus intravenous oxytocin for the third stage of labor after vaginal delivery to prevent postpartum hemorrhage: a meta-analysis of randomized controlled trials. European Journal of Obstetrics & Gynecology and Reproductive Biology, 250(2019), 265–271. https://doi.org/10.1016/j.ejogrb.2020.04.007